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Furthermore, recent studies also demonstrate that HuD is required for mechanisms of learning and memory in mature hippocampus and peripheral nerve regeneration (Bolognani et al., 2004; Pascale et al., 2004; Anderson et al., 2003; Deschênes-Furry et al., 2007).
The structural plasticity of spines is thought to complement functional plasticity (e.g., LTP and LTD) and play a central role in learning and memory in mature animals (Bourne and Harris, 2007).
Activity-induced persistent synaptic modifications are generally thought to be the cellular mechanism underlying developmental refinement of neuronal connections (Zhang et al. 2001), as well as learning and memory in mature animals (Bliss and Collingridge 1993; Chapman et al. 1999; Martin et al. 2000).
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Brain-derived neurotrophic factor (BDNF), a neurotrophin, is known to promote neuronal differentiation stimulating neurite outgrowth in the developing CNS, and is also known to modulate synaptic plasticity, thereby contributing to learning and memory in the mature brain.
Activity-dependent persistent synaptic modifications are generally thought to be the cellular mechanisms underlying the refinement of neuronal connections in the developing nervous systems [10], [11] and contributing to the processes of learning and memory in the mature brain [12], [13].
The quest for non-volatile memories has attracted tremendous attention, especially in mature ferroelectric random access memory (FeRAM) with properties of high read/write speed and low power consumption.
In another study, Curtale and colleagues [ 36] showed that miR-146a is involved in T-cell activation and is highly expressed in mature human memory T cells.
This miRNA would appear to be a master regulator for several aspects of immunity, including the regulation of cytokines, such as tumor necrosis factor-alpha (TNF-α), functioning in the negative feedback control of innate immunity in Toll-like receptor (TLR) signaling, and is involved with T-cell activation and is highly expressed in mature human memory T cells [ 41].
Kim and colleagues examined the role of Cdc42 in synaptic plasticity in mature neurons and in behaviors such as learning and memory in adult animals.
Neurogenesis in the hippocampal DG is an active process in mature CNS and plays a key role in synaptic plasticity, memory and learning (Abrous et al., 2005).
Moreover, analyzing blood from a WAS patient with a revertant mutation, we observed a proportional increase in WASp+ cells in mature versus transitional B cells and further enrichment within the memory B-cell compartment, findings consistent with a selective advantage for WASp+ follicular mature and memory B cells.
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