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Therefore, we conclude that the observed contextual episodic and spatial working memory impairments observed in SDV and CCK-SAP rats are unlikely to be secondary to surgical effects on body weight regulation.
The former observation suggests that the learning and memory impairments observed in jet-lagged animals did not result from perturbations in circadian rhythmicity, but from desynchrony between internal physiology and external time.
In order to verify that any of the memory impairments observed upon shibirets1-dependent block of synaptic transmission were due to impaired odor perception, we presented these cues to naïve larvae under the same conditions as for the associative assays.
To verify that the memory impairments observed by manipulation of DA receptor function were not simply due to impaired odor, salt or sugar perception, we performed control experiments in which these cues were presented under the same conditions as for the associative assays.
Thus, observed contextual episodic and spatial working memory impairments observed in SDV and CCK-SAP rats are unlikely to be secondary to effects on anxiety-like behavior.
Finally, we tested if the memory impairments observed upon shibirets1-dependent block of synaptic transmission were not simply due to impaired salt or sugar perception.
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The profile of memory impairment observed in Alzheimer's disease selective impairment of MTL-dependent memory including impaired spatial memory (57) with often striking preservation of procedural memory (58)—is similar to what we describe here.
The episodic memory impairment observed in MCI and early AD using explicit memory tasks frequently overlaps [ 23, 24] albeit not all MCI patients will progress to AD.
There seems to be a relationship between the episodic memory impairment observed in patients with MCI and AD and their difficulties in processing emotional information.
The present study demonstrated that the cognitive deficits and memory impairment observed after SCO-induced hippocampal lesion are closely related to the degeneration of cholinergic neurons and the BDNF-CREB pathway; acupuncture stimulation at GV20 significantly ameliorated spatial memory deficits through recovery of the ACh system.
Therefore, AG may be efficacious in attenuating memory impairments often observed in schizophrenia patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com