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Rech, R. L. et al. Reversal of age-associated memory impairment by rosuvastatin in rats.
De Lima, M. N. et al. Reversion of age-related recognition memory impairment by iron chelation in rats.
Gupta, V. K. et al. Spermidine suppresses age-associated memory impairment by preventing adverse increase of presynaptic active zone size and release.
Further, the most potent compound 1g was selected to evaluate the effect on the acquisition and memory impairment by mice step-down passive avoidance test.
Exercise most likely ameliorated isoflurane-induced memory impairment by enhancing hippocampal histone acetylation and activating more neuron cells during memory formation.
The present results, demonstrating increased IL-1β mRNA expression in the hippocampus of aging Tg2576 mice, and rescue of the AD-associated hippocampal-dependent spatial memory impairment by NPCs that secrete IL-1ra specifically in this structure, indicate that the effects of IL-1 blockade occur directly within the hippocampus.
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Consistent with previous reports, APP mice develop memory impairments by 8 9 months when compared to age-matched WT or CCL2 littermates (T4 and T5, Fig. 1B).
Though beneficial effects of lithium have been previously described in different AD models, here we report a novel in vivo action of this compound that efficiently ameliorated AD-like pathology progression and rescued memory impairments by reducing the toxicity of Abeta plaques.
Diabetes-induced learning and memory impairment, characterized by impaired cognitive functions and neurochemical and structural abnormalities, involve direct neuronal damage caused by intracellular glucose.
Alzheimer's disease (AD) has been considered clinically homogenous and characterized by progressive memory impairment followed by global cognitive decline [ 1].
Acupuncture stimulation at GV20 alleviates the spatial memory impairment induced by cerebral multi-infarction, as evaluated by shortened escape latency and increased swimming time in the target quadrant in rats [ 59].
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