Theta phase precession has not been reported in other species, while theta oscillation in the hippocampus has been considered to be important for the memory function commonly observed in many species.
This could explain why improved memory function was observed in the same mouse model when phenylbutyrate was administered (Ricobaraza et al, 2009) and the fact that SAHA could rescue age-associated memory impairment in mice when injected directly into the hippocampus (Peleg et al, 2010).
Nominal change in auditory comprehension and untrained attention and memory functions was observed, and neither RW nor his spouse reported noticeable improvements in his daily attention or communication abilities.
Among subjects with lower episodic memory level 2 functioning, observed percentages of conversion with and without lower cognitive flexibility were 66.7% versus 57.5% (18 out of 27 versus 23 out of 40).
The opposite pattern (normal subjective memory complaints in the face of objective memory function) may be observed in patients with poor frontal lobe function, such as patients with vascular dementia or advanced dementia [ 20, 21].
The functional adequacy model on the other hand suggests that it is the capacity of the ipsilateral hippocampus, which is to be resected, that determines whether changes in memory function will be observed.
According to the hippocampal reserve theory, postoperative memory decline depends on the capacity or reserve of the contralateral hippocampus to support memory following surgery, while the functional adequacy model suggests that it is the capacity of the hippocampus that is to be resected that determines whether changes in memory function will be observed.
Local infusion of the nicotinic antagonist methyllycaconitine (MLA) to block α7 nicotinic receptors and dihydro-β-erythrodine (DHβE) to block α4β2 nicotinic receptors into the basolateral amygdala and the ventral hippocampus have been found to impair working memory function, with no additive effects being observed.
Local infusion of the nicotinic antagonist methyllycaconitine (MLA) to block alpha7 nicotinic receptors and dihydro-beta-erythrodine (DHbetaE) to block alpha4beta2 nicotinic receptors into the basolateral amygdala and the ventral hippocampus have been found to impair working memory function, with no additive effects being observed.
These postoperative effects were not observed for visual memory function after right anterior temporal lobe resection.
