Although false memories are formally a kind of memory distortion, for proper adaptation it might be useful especially in situations of restricted cognitive control (as in a state of sleep deprivation) to rely on the gist of a memory, i.e. the broader semantical network associated with actually experienced events.
34, 53, 54 Therefore, global modification of the methylome with epilepsy compromises transcriptional regulation of memory-permissive genes in the hippocampus that is required for proper memory formation.
If your memory stick has software files on it that came with the stick, leave them on, as they may be necessary for proper memory stick function.
10, 17 Therefore, we hypothesize that a consequence of TLE-associated DNA methylation changes is that normal transcription of neuronal genes required for proper memory formation, such as Bdnf, are severely compromised in the epileptic hippocampus and contribute to epilepsy-associated memory deficits.
Figure 5 shows the performance of younger adults as a function of the performance of older adults for conditions with focal vs. non-focal cues, for prospective memory proper and for vigilance (no studies of event cued habitual prospective memory were identified in the review, see Uttl [2], for a more extensive discussion of this point), for confound free age-contrasts only.
51 It is reasonable to speculate that decreasing BDNF expression in an epileptic brain might decrease hyperexcitability to allow for proper memory formation with epilepsy.
BDNF activity is crucial for proper memory formation and is significantly increased with epilepsy in both rodent models and in humans.
The hippocampus is critically important for proper memory function [ 35], and recent studies have shown that this brain structure is severely affected in MS [ 16, 26].
15, 16, 18, 28 Furthermore, Bdnf transcriptional activation in area CA1 of the hippocampus is necessary for proper memory formation and CA1 is also a region affected with chronic seizures in TLE.
