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In recent years, other forms of central sensitization have been found which involve activity-dependent increases in synaptic efficacy of these relay neurons, with varying onset latencies and memory durations reflecting distinct transcription-dependent or -independent cellular events [ 59, 60].
Participants were clearly able to perform the task and to discriminate the contrast changes between the comparison and test stimuli, but they showed elevated thresholds with increasing memory durations (Fig. 2a).
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In contrast, the effect of spatial memory duration was mediated by the level of prey spatial aggregation.
In summary, the discordance between the short half-lives of this major class of modified biomolecules implicated in memory formation and memory duration is extreme.
But these results only increase the concern for Crick's paradox, because more rapid TET-dependent turnover works against 5MeC-dependent memory duration.
In particular, for 2-D pixel noise patterns, discrimination thresholds increased as the memory duration increased from 0.3 to 5 s.
Crick's model highlighting the importance of rapid molecular turnover and molecular symmetry to memory duration has, with few exceptions, been overlooked in the literature [ 3, 9, 10].
The duration that the immunologic response to Leishmania antigen remains after therapy may be an indicator of memory duration after infection with Leishmania and this information will be relevant in vaccine development for leishmaniasis.
Consequently, stimuli with a physical duration equal to the reference memory duration are perceived as longer when they are auditory and as shorter when they are visual (Penney et al., 2000).
In summary, the role of the Gadd family of repair proteins in the turnover of DNA methylation and memory duration remains an important problem worthy of further study, in spite of the apparent complexity of various published reports.
The machinery responsible for the predominant DNA 5MeC de-methylation activities contributing to turnover has been difficult to pin down in any tissue, let alone de-methylation in the brain, which might impact memory duration [ 21].
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