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This program is proposed as an intervention for ADHD that targets working memory deficits with specific exercises through intensive training sessions.
The present study was designed to assess the effects of dorsal hippocampal (CA1) GABAb receptors on ketamine-induced spatial and non-spatial memory deficits with regard to the role of Ca2+ as a defining factor.
However, epilepsy results in exacerbated levels of BDNF, which may contribute to memory deficits with epilepsy.
Individuals with medial temporal lobe epilepsy have significant material-specific episodic memory impairments, with greater verbal and visual memory deficits with left and right temporal lobe epilepsy, respectively.
In line with these findings, treatment of wildtype mice using intraventricular Aβ injection induced significant working memory deficits with Aβ4-42, pyroglutamate and-42 and Aβ1-42.
The transgenic mice exhibited severe learning and memory deficits with progressive development of amyloid plaques and NFTs as previously described (Oddo et al. 2003).
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Together, the two experiments further confirm that patients with semantic dementia show a modality independent autobiographical memory deficit, with better retrieval of recent events.
For example, crammer mutant flies were reported to either show or not show an appetitive short term memory deficit with identical memory retention scores, because the scores of the control "CS" flies were different in the two studies.
Indeed, patients with depression suffer from an increased self-focus (i.e. link negative affect and episodic memory deficit with an increased attention to the self) [ 46], and exaggerated self-processing (i.e. the appraisal of stimuli as strongly related to one's own person) [ 47].
This speculation is also consistent with the above cited animal studies indicating that developmentally regulated over-expression of striatal D2 receptors is associated with behavioral working memory deficits and with altered activity of the prefrontal cortex [12].
56 Nonetheless, we found that methyl supplementation with Met could reverse memory deficits associated with epilepsy using two hippocampus-dependent rodent memory paradigms.
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