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ANOVA followed by Bonferroni post-hoc tests revealed no main effects and no individual differences among the four quadrants, suggesting a remote memory deficit of cKO mice.
Thus, consistent with the LTP data, β-secretase-inhibitor IV and MoBA rescued, albeit temporarily, the memory deficit of FDDKI mice, while the GSI did not.
Even this 10-fold higher GSI dose did not correct the memory deficit of Danish mice, and GSI-treated WT mice showed a trend, though not statistically significant, towards memory impairment (Fig 4B).
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Our study clearly demonstrates the feasibility of virtual reality technology to study spatial memory deficits of persons with aMCI.
This study tested the hypothesis that a modified dry-land version of the multi-choice Biel-maze task is more sensitive than the rewarded-alternation Y-maze task for the determination of spatial learning and memory deficits of ethanol teratogenicity.
We designed our study to test the effect of carnosine supplementation on AD-like memory deficits of 3xTg-AD mice.
We next investigated whether culling could also reduce learning and memory deficits of neonatal DEX-treated rats measured in the object recognition and passive avoidance tests.
Since this form of memory is known to be dependent on a number of brain structures, including gustatory cortex and amygdala [24], [25], [26], these results attest to the specificity of the remote memory deficits of these two mutant strains.
Preventive and therapeutic MB application failed to avert or recover learning and memory deficits of TauRDΔK mice.
Five weeks after surgery, we analysed the effect of β-secretase-inhibitor IV, MoBA and GSI on the memory deficits of FDDKI mice in a longitudinal study.
Finally, tau hyperphosphorylation has been linked to the memory deficits of different mouse models of human neurodegenerative diseases (Lee et al., 2001; Kurz & Perneczky, 2009).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com