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Our study highlights differences and similarities in the source of the episodic memory deficit found in patients with SZ and their unaffected parents, and it suggests that recollection could act as a cognitive endophenotype of SZ.
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Our results suggest that the deficits in spatial learning and memory that resemble memory deficits found in schizophrenia patients are better modeled by PCP in LH rats than Wistar rats.
Thus, future experiments will be aimed at utilizing pharmacological manipulations to investigate the relationship between decreases in mPFC DA induced by adolescent social defeat and the observed spatial working memory deficits found in the present study.
Evidence for the former account comes learning and memory deficits found after infusions of antisense that block c-Fos activity (He et al., 2002; Seoane et al., 2012; Katche et al., 2013).
When the behavior of APP23 mice was investigated, major learning and memory deficits were found as early as 3 months [17].
Working memory deficits are found in different psychiatric populations and are most pronounced in schizophrenia.
An exception is the study by Canfield et al. (2004), in which increased errors on the spatial span and spatial working memory tasks from the CANTAB battery, suggestive of spatial working memory deficits, were found to be associated with higher BLLs.
Smith and collaborators [ 12] studied a group of MCI patients diagnosed on the basis of memory deficits and found that APOE ε4 was associated with poorer performance on tests of learning and recall in MCI patients, but not in normal controls.
"Potentially this could account for the memory deficits we find in depression and other disorders too".
Impairments in processing speed, attention, working memory, verbal memory and problem solving are the most common cognitive deficits found in patients suffering from bipolar disorder (Mann-Wrobel et al. 2011; Martinez-Aran et al. 2000; Daglas et al. 2015).
Memory deficits have been found in several lines of mice with mutations impacting the generation of robust circadian rhythms in behavior [8], [21] [26].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com