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There was no significant correlation between language lateralization index and visual memory decline after right ATLR.
Greater right than left anterior hippocampal activation asymmetry for encoding faces was correlated with greater visual memory decline after right ATLR (P = 0.063, family-wise error corrected).
> -wrap-foot> We report a series of investigations of memory fMRI in temporal lobe epilepsy, and the ability of the method to predict memory decline after ATLR.
In patients with left temporal lobe epilepsy there was no significant correlation between preoperative verbal learning scores and verbal memory decline after left ATLR (Pearson's correlation coefficient, r = −0.037; P = 0.42) (one-tailed).
Previous studies by our group have demonstrated the advantages of an event-related analysis for evaluating verbal and/or visual memory decline after ATLR (Richardson et al., 2004; Powell et al., 2008).
Most previous studies have focused on the prediction of verbal memory decline; only a few have investigated visual memory decline after non-dominant ATLR (Rabin et al., 2004; Janszky et al., 2005; Powell et al., 2008).
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"When we separated out the cognitively impaired individuals, we found no evidence of further memory declines after the age of 69 in samples of nationally representative older adults and highly educated older adults," said Reyna.
Psychological symptoms and memory decline were common three months after knee replacement in our patients over the age of 65 years.
The effects may be protracted: one study reports ongoing verbal memory decline up to 9 years after left temporal surgery (Rausch et al., 2003), and two others report short-term decline followed by stabilization or recovery after 6 10 years (Alpherts et al., 2006; Andersson-Roswall et al., 2010, 2012).
Greater right than left fMRI activation for encoding faces in the right anterior medial temporal lobe was correlated with greater visual memory decline (R2 = 0.22, P = 0.02) after right ATLR.
The 65-year-old patient with the M232R mutation showed rapidly progressive memory decline and gait disturbance, and died within 16 months after onset of symptoms.
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