Sentence examples for memory conversion of from inspiring English sources
Cellular memory — conversion of a transient signal into a sustained response — is a common feature of biological systems.
Our results prompted us to investigate the signals that are necessary to enhance memory conversion of the late transferred cells.
In parallel to these experiments, we were able to recapitulate the enhanced memory conversion of P14 early transferred naïve CD8 T cells after recombinant IL-7 treatment as previously described (30) (data not shown).
In order to identify parameters other than viral antigenic load that differ and could affect memory conversion of antiviral CD8 T cells, mice that had received naïve P14/GFP+ cells late were treated the day after the cell transfer with polyI C (100 µg/mouse), CpG (200 µg/mouse) or recombinant IFNγ (50 ng/mouse).
Exogenous treatment with inflammatory stimuli could not reverse preferential memory conversion of the late recruited cells, suggesting that the antigenic load is likely the main factor that contributes to memory formation, possibly determined by the number of T cell to APC contacts.
It is evident from the results discussed above that the majority of naïve T cells recruited late during the immune response displayed a higher degree of memory conversion in the spleen.
As shown in Fig. S1, treatment with any of these three regiments did not alter memory conversion.
Antigenic load, costimulation, CD4-help, cytokines and chemokines fluctuate during the course of an antiviral immune response thus affecting CD8 T cell activation and memory conversion.
In addition, full differentiation into effector cells is not prerequisite for memory conversion [39].
Finally, a farming environment was associated with lower proportions of FOXP3+CD25high T cells in early infancy and to a more prominent T cell memory conversion and cytokine production.
Viral replication and immune activation following TI increase interactions between HIV or envelope proteins and CD4 or HIV-co-receptors, and may favor the peripheral conversion of memory activated CD4 T cells into Treg [40].
