First, regarding the episodic memory condition, bilateral activations of the middle and superior frontal gyri and precuneus (more prominent on the right side) were observed.
The memory condition required the memorization of three pairs of unrelated elements, e.g., after the presentation of three pairs of objects: G T, U R, and W S, every subject was asked whether the presented pair of letters was shown before or not.
In the working memory condition, the task required recollection of a stimulus seen two stimuli (2-Back) previously while continuing to encode additionally incoming stimuli.
We continued to model σ in each memory condition as a multiplicative factor of σ in the baseline condition, so that σ memory + illumination = k∗ σ baseline.
The same stimuli were used for the primary priming task in each of the three memory condition experiments, presented in three separate sessions.
The present study replicates these findings insofar as we find activity in the perirhinal cortex (on the right in the present study) that predicts subsequent memory irrespective of the associative memory condition and activity in the hippocampal region and the parahippocampal cortex that predicts subsequent successful associative memory.
Interestingly, after chronic vmPFC HFS, there was also a positive correlation for the short-term memory in condition of no-HFS prior to the NOR testing with the Dcx cell count (r = 0.674, p = 0.045) and NeuN/Rbfox3 gene expression (r = 0.834, p = 0.011).
Reviewer #1: The authors investigate a special form of memory, conditioned taste aversion (CTA) which can be often learned in a single trial.
They tested this hypothesis in an experiment with two working memory conditions, with and without the necessity of manipulation of objects.
Each participant took part in three sessions, in order to complete each of the memory conditions; zero, two and six words.
