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To address such challenges, recent neuroimaging studies have focused on middle-aged and older adults with only mild memory complaints and evaluated results according to the major known genetic risk for Alzheimer's disease, the apolipoprotein E-4 (APOE-4) allele.
Primary aim of the questionnaire is to check two criteria for MCI, memory complaints and normal activities of daily living.
This item was dichotomised, with a score of 1 2 denoting subjective memory complaints and 3 4 no impairment.
Memory complaints are assessed by the question 'do you have memory complaints' and the cognition scale of Strawbridge [ 50].
French-speaking elderly subjects of at least 60 years were included in the study group if they had memory complaints, and low memory and/or attention performance.
They were screened to exclude those with memory complaints, and they underwent the same neuropsychological examination as the other two groups.
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Memory complaint and assessment of general cognitive function were the most consistently measured criteria.
The prevalence of many symptoms increases with worsening cognition, the presence of a subjective memory complaint and impaired functional ability.
29 In our study, however, the association between memory concern and cognition was independent of the links between memory complaint and self-rated memory function, and negative affect.
This heterogeneous group includes both respondents with an objective memory impairment but no subjective memory complaint, and those with impaired general cognitive function but not diagnosed with dementia.
However, in multivariate analysis adjusting for subjective memory complaint and cognitive function, those with an objective memory disorder were not found to be at higher risk.
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