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The CD8+ CD44hi memory compartment is particularly affected.
Compared with the naive population of T cells, the memory compartment is clearly contracted in diversity.
Interestingly, the virtual memory compartment is also a hallmark of the ageing adaptive immune system.
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These T-cell memory compartments are frequently referred to as 'naive' (TNAIVE = CD45RA+/CD27+), 'central memory' (TCM = CD45RA−CD27+), 'effector memory' (TEM = CD45RA−CD27−), and 'revertant' (TEMRA = CD45RA+CD27−).
It is clear, however, that disturbances of early stages of B-lymphocyte homeostasis are also present in SLE and indicate that not only memory compartments are affected.
Although CMV establishes latent infections, which are asymptomatic in the immunocompetent host, the impact of CMV on the memory T cell compartment is substantial.
As shown in the graphs below, Vav-Atg5-/ are both lymphopenic and accumulate the "virtual" memory compartment, which is identical to the phenotype observed in Vav-Atg7-/.
In these patients, the memory CD8+ compartment was similarly affected.
Thus, the memory CD4+ T cell compartment is largely intact in the absence of IL-6 signaling in T cells, regardless of the presence of Tregs.
Other studies have used HTS to provide unexpected insight into the naive and memory T-cell compartments, revealing that the memory compartment may be far more diverse than previously thought (Klarenbeek et al., 2010; Robins et al., 2009; Venturi et al., 2011).
Here we show that this less abundant CD8+ T cells compartment is not of the effector-memory phenotype, as in healthy subjects.
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CEO of Professional Science Editing for Scientists @ prosciediting.com