Even in the case where ACPA IgM-producing memory B cells exist, it is still interesting that such cells are present only against certain citrullinated antigens.
In addition to an effector T cell subset, both naïve and memory CD8+ T cells exist within the peripheral CD8+ T-cell pool (Hamann et al, 1997; Young et al, 1997; Sallusto et al, 1999; Baares et al, 2000).
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Analysis by various groups [ 22, 24, 70, 71] indicates that CD27- naive, CD27+ memory B cells and CD27high plasmablasts/plasma cells exist in relatively stable relations in the peripheral blood of healthy adults, although the frequency of CD27+ memory B cells reflects the accumulation of antigen experience of an individual that is, at least in part, dependent on age [ 71].
Same cells exist in both.
If the memory pool is limited, memory cells have to be replaced after the memory compartment has filled up.
However, cellular salvage pathways for proliferation exist and allow slowly dividing T memory cells to sustain ongoing pyrimidine metabolism and to survive [ 125].
Thus, if a difference in learning rate between associative memory and item memory existed, then the discriminative power of the associative memory test for aMCI should increase more than that of the item memory test with increasing learning trials.
Therefore, amongst CD4+ T-cell subsets, distinct requirements for costimulatory molecules exist, which are also likely different for naive and memory cells.
