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Although animals exposed to or non-exposed to isoflurane developed spatial learning, animals exposed to isoflurane had significant impairments in long-term spatial memory assessed by Barnes maze.
Daily oral posttreatment with EGb 761 led to a significant recovery of spatial memory assessed by the object location test, inhibited the decrease in plasma SOD activity and protected the hippocampal CA1 neurons, even when administered after the insult.
Then fear memory assessed by freezing behavior was measured at three time points following training.
Giakoumaki et al. found that tolcapone, the COMT inhibitor, enhanced working memory assessed by the letter number sequencing tasks in healthy subjects with the Val/Val genotype [ 33].
These were: 'psychomotor speed', assessed using the Trail-Making Test, part A (TMT A); 'mental flexibility', assessed by part B (TMT B) [ 63, 64]; 'verbal learning and memory', assessed by the Rey Auditory Verbal Learning Test (RAVLT) [ 64] using the sum of trials RAVLT A1-A5 (leanding), and 20-minute delayed recall by RAVLT A7 (memory).
MCI patients were required to have a subjective memory complaint associated with isolated impairment in episodic memory, assessed by a free recall total score (based on the FCSRT) of less than 1.5 SD from the means for their age and education level.
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Table 1 Instruments for the diagnosis of delirium in the ICU Instrument Assessment features Assessment method Diagnosis Abbreviated Cognitive Test for delirium [36] Total score obtained by summing up two content scores: attention (range 0 14) and memory (range 0 10) Memory is assessed by recognition of pictured objects.
Visual memory span and working memory was assessed by the subtest spatial span forward and backward from the revised German version of the Wechsler Adult Intelligence Scale [33].
Df(10 1Yey mice showed impairment in spatial and learning reference memory as assessed by the Morris watermaze test and associative memory as assessed by fear conditioning test.
The main effect of memory was assessed by weighting all 4 conditions containing the memory parameter over baseline.
However, only the pro-aggregant mice showed memory deficits, while the anti-aggregant displayed normal memory, as assessed by Morris water maze and the passive avoidance task.
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