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Remote spatial memory as assessed by the SAM showed the expected advantage for males over females.
The rodent hippocampus plays a well-established role in spatial memory, and we previously demonstrated that temporary inactivation of the mouse hippocampus impairs object memory, as assessed with a novel object preference (NOP) test.
Specifically, we examined whether the retrieval of spatial memory (as assessed by the Morris water maze; MWM) and object recognition memory are differentially sensitive to inactivation of the CA1 region.
There were no significant differences between groups in spatial learning and memory as assessed by the Rey-Osterrieth Complex Fimmediatet in immediand andelayeded recall and in the Cambridge Neuropsychological Test Automated Battery for pattern and spatial recognition and paired associates.
A visuospatial learning test was performed to assess the animals' ability for non-olfactory learning and memory (as assessed by re-learning).
For the TPH2KO and DKO, there were no differences between the KO or DKO and WT littermate control mice in motor coordination, acoustic startle response and sensorimotor gating, tonic inflammatory pain sensitivity, and learning and memory as assessed in inverted screen, pre-pulse inhibition, formalin paw, and trace fear conditioning assays, respectively (Table 4).
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To test the value of the ICUM tool [ 15], the relationship between the presence of clear memories, as assessed using the ICUM tool, and duration of stay in the ICU was analyzed.
starting from the first dose of STZ for 28 days showed a dose dependent improvement in STZ induced memory deficits as assessed by Morris water maze (MWM) test.
The chaperones were found to prevent Aβ42-induced learning and memory impairments, as assessed by the Morris Water Maze test, and reduce Aβ42-induced glia inflammation and neuronal degeneration in rat brains, as probed by fluorescent immunohistochemical analyses.
In vivo, EH-201 treatment restored memory impairment, as assessed by the passive avoidance test, in SD, Aβ and KA mouse models.
Problems in neurocognitive functioning include attention problems, problems with information processing speed and/or memory problems as assessed by caregiver report.
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