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Apicomplexa possess numerous unusual features in their membrane trafficking systems.
The difference in expression of clathrin and the formin-like FH2 domain containing transcript between juvenile and mature cuttings, suggest differences in remodeling of the actin and membrane trafficking systems during AR induction.
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STING forms a membrane trafficking system that mediates the dynamic translocation of STING and leads to the effective induction of innate immune responses (Saitoh et al., 2010), but the interaction between PLpro-TM and STING prohibits the membrane trafficking of STING, which results in inhibition of phosphorylation and dimerization of IRF3 and blocks IFN signaling transduction (Fig. 6B).
Consistent with our observations, Onda et al. [23] recently demonstrated that intravenously administered ICG was passively internalised by the endocytic activity of tumour cells and entrapped in the membrane trafficking system, resulting in its slow turnover and prolonged retention by tumours.
Trypanosomes undergo major changes in their membrane trafficking system, surface antigen expression, cell structure and metabolism during the transition from mammalian to insect host, and the differentiation program from BSF to PCF has been well-studied [5], [11].
The eukaryotic membrane trafficking system is a network of membrane-bound organelles and protein machinery for transporting material between them.
These data suggest that significant transcriptional level remodelling of the membrane trafficking system accompanies life-cycle progression in trypanosomes.
These cells display a most elaborate membrane trafficking system, with distinct, predictable pathways in which actin could participate.
Isotropic and polarized distribution of Cdc42 in yeast is required for polarized organization of the cytoskeleton and membrane trafficking system.
Differentiation encompasses considerable remodeling of the membrane trafficking system, which is also a vital component of the host-parasite interface.
Understanding the relationship between these complexes would help us to understand how a highly complex membrane trafficking system evolved from an ancestor with no internal membrane compartments.
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