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Among these overlapping cellular functions are components of intracellular membrane trafficking pathways.
Specific PIPs are also used to regulate various steps of intracellular membrane trafficking pathways.
SNARE proteins control the membrane fusion events of membrane trafficking pathways.
The substrates for most RabGAPs are unknown, and the potential for cross-talk between different membrane trafficking pathways remains uncharted territory.
1. Mechanisms by which emerging viruses hijack intracellular membrane trafficking pathways for mediating viral assembly, release, and direct cell-to-cell spread.
Here, we review recent discoveries focused on how viruses exploit intracellular membrane trafficking pathways to promote various stages of their life cycle, with an emphasis on cellular factors that are usurped by a broad range of viruses.
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In light of these previous studies, we can hypothesize an intracellular function of matricellular proteins active in the membrane trafficking pathway.
In order to assess the Golgi-to-endosome or Golgi-to-plasma membrane trafficking pathway, the localization of GFP-Syb1 was monitored.
In contrast, GFP-Syb1 failed to localize at the cell surface and the cell ends of Δrho3 and Δapm1 cells (Figure 4A), suggesting that Rho3 is also involved in the Golgi/endosome membrane trafficking pathway.
Molecular studies have shown that Unc-51 controls axon formation in the granule cells through the endocytic membrane trafficking pathway via directly binding the synaptic GTPase activation protein (SynGAP) and Syntenin, which is a PDZ domain-containing scaffolding protein that binds Rab5 GTPase and is involved in endocytic vesicular turnover [14].
The secretory and endocytic pathways constitute the main membrane trafficking pathway in cell (Sallese et al., 2006; Brandizzi and Barlowe, 2013).
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membrane receptor pathways
membrane fusion pathways
membrane transport pathways
membrane trafficking systems
membrane efflux pathways
membrane uptake pathways
membrane trafficking architectures
membrane signalling pathways
membrane ion pathways
membrane trafficking processes
membrane trafficking machineries
membrane traffic pathways
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