Sentence examples for membrane traffic defects from inspiring English sources

Membrane traffic defects might cause cell integrity defects.

We hypothesized that these strains could be defective for delivery and/or retention of the major K+ transporter, Trk1, at the plasma membrane because of the membrane traffic defects, although our previous studies demonstrated that this was not the case for the arl1Δ mutant (Munson et al., 2004a).

A heterogeneous class of diseases united under the name of lipid storage diseases leads to the pathological accumulation of specific lipids in late endosomes, which are subsequently thought to trigger membrane trafficking defects [12], [13].

Membrane trafficking defects are observed in SCs when protein secretion is disrupted.

A membrane trafficking defect was observed in soma of sensory neurons expressing mutant dSpt1, consistent with endoplasmic reticulum (ER) to Golgi block.

Nearly 80% of these membrane traffic defective strains showed defects in uptake of the K+ homolog, Rb+.

Thus, Δapm1 and Δrho3 cells have very similar phenotypes in terms of membrane-trafficking defects and sensitivity to ion- and cell wall-damaging agents.

This suggests that ATP8A2 in neurons is essential for recycling membrane traffic and defects in this pathway provide a molecular mechanism for CAMRQ.

In summary, as shown in Figure 2 and Table S3, the vast majority of the hygromycin B-sensitive membrane traffic mutants were defective for uptake of Rb+, a more specific test of K+ defects than hygromycin B sensitivity.

We cannot exclude the possibility that OCRL1 participates in APPL1-mediated Akt signalling, but our data are more consistent with reduced Akt signalling arising from defects in membrane traffic.

The importance of proper membrane traffic is demonstrated by the ubiquity of genes with defects in this process in results of nearly all genome-wide deletion screens.