Sentence examples for membrane to activate from inspiring English sources
If the affinity of Gβγ for GIRK is so low and the interaction so transient, how does GPCR activation ever achieve sufficiently high concentrations of Gβγ in the membrane to activate the channel?
The action potential propagates over the muscle fibre membrane to activate the contractile process.
Cong, F., Schweizer, L. & Varmus, H. Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.
PMA mimics DAG in the cellular membrane to activate PKC.
The Calcium Influx Factor (CIF) is a specific factor produced by the cells following depletion of Ca2+ stores [51] and corresponds to the diffusible messenger that is produced by Ca2+ stores upon their depletion traveling to the plasma membrane to activate SOCs and Ca2+ entry [43].
They transduce extracellular signals across the membrane to activate intracellular signaling cascades via heterotrimeric G proteins.
Third, voltage-activated Ca2+ channel (VACC) antagonists reduced transients by half, suggesting that swelling-activated channels depolarize plasma membranes to activate VACCs.
In CICR, the action potential opens L-type calcium channels (dihydropyridine receptors -DHPRs) in the surface membrane and t-tubular membranes to activate the sarcoplasmic reticulum (SR) ryanodine receptors (RyRs) to cause release of Ca2+ from the SR.
So Carboxy PTIO was without effect on the GIR which indicates that NO produced within the nerve fibres during the conduction of excitation without action potentials does not diffuse sufficiently through the neuronal membranes to activate other fibres.
The central 5′-phosphatase domain dephosphorylates phosphatidylinositol bis- or trisphosphates, localized in plasma membranes, to activate downstream pathways [ 6, 8, 11, 12].
While ipRGCs are subject to ionotropic GABA and glycine-gated inhibitory currents [19], [20], these probably do not hyperpolarize the membrane sufficiently to activate Ih because the Cl− reversal potential presumably lies close to the resting membrane potential and well positive to the Ih activation threshold.
