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Our current findings, therefore, reopen the debate about how Rab GTPases, Rab effectors, and tethering factors work together to mediate specific membrane tethering processes in secretory and endocytic membrane trafficking pathways.
However, how exactly Rab GTPases themselves act upon membrane tethering processes has remained enigmatic.
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The physiological function of non-bilayer lipids in membranes is considered to reside in their interaction with membrane proteins via the membrane lateral pressure and membrane tethering and fusion processes, which are relevant for autophagy.
This indicates that the Rab-mediated membrane aggregation found here is a reversible process of membrane tethering and can be reversibly regulated by membrane attachment and detachment cycles of Rab proteins.
Armadillo (ARM) repeat proteins function in various cellular processes including vesicular transport and membrane tethering.
Diverse membrane fusion processes occur in cells through a common set of steps: membrane tethering, docking, and fusion (Brocker et al., 2010; Li and Chin, 2003).
Diao, J. et al. ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
Nakatogawa H, Ichimura Y, Ohsumi Y. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.
Nakatogawa, H., Ichimura, Y. & Ohsumi, Y. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.
SNAREs are known function in membrane tethering and fusion and play key roles in plant development.
SNAREs are well known as key players that function in membrane tethering and fusion.
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