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Conversely, membrane targeting of Flt3-ITD strongly activates the MAPK and PI3K pathways, with diminished phosphorylation of STAT5.
Killing kinetics and fluorescence spectroscopy suggest membrane targeting of TetraF2W-RR, making it more difficult for bacteria to develop resistance.
In mammalian systems, Rab10 has been implicated in mediating membrane targeting of plasmalemmal precursor vesicles (PPVs) during axon development (Xu et al., 2014).
However, unlike in mammalian cells, the inhibitor peptide does not abolish membrane targeting of Bax [35].
The detailed mechanism of membrane targeting of Kv potassium channels is poorly understood [6].
Cell proliferation and membrane targeting of angiogenic receptors (e.g. VEGFRs) are highly dependent upon normal ER functions.
In summary, we have shown for the first time that membrane targeting of sCD59 is not required to inhibit MAC formation in vivo.
Additionally, the budding rescue assays described above suggested that MA-dependent membrane targeting of PRE-dependent HIV-1 Gag was apparently deficient in human cells.
In addition to the formation of patchy structures, increased plasma membrane targeting of SlSUT1-GFP has been reported in response to different treatments with oxidizing agents [7].
Plasma membrane targeting of CD95 is important for proper CD95/CD95L interactions and transduction of the apoptotic signal as shown earlier.
According to a common model of the bacterial SRP pathway [23], Ffh has an essential role in membrane targeting of ribosomes translating membrane proteins.
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