Sentence examples for membrane sorting from inspiring English sources

Polarized cell architecture is established through membrane sorting pathways that are regulated by specialized transport machinery, which includes an extensive array of regulatory macromolecular complexes.

To this end, we have designed a lipoprotein expression vector (pDUMP) that results in the production of fusion proteins containing the E. coli major outer membrane lipoprotein (Lpp) signal sequence, lipoprotein signal peptidase recognition site, and the +2 outer membrane sorting signal at their N termini.

Additionally, following membrane sorting upon cytokine stimuli, E-selectin undergoes a recycle phase, rapid internalization to endosomes and subsequent partial lysosomal degradation.

Members of this family of GTPases are important regulators of intracellular membrane sorting.

Our data suggest that NHERF2 may act as a plasma membrane sorting site, providing a novel regulatory mechanism to control the intracellular spatial and temporal effector protein activity.

The focus of this manuscript is the mechanisms underlying the competitive outcome in antagonistic motor ensembles and their impact on the collective function of myosins in membrane sorting.

Here we report that, in muscle cells, GLUT4 internalized from the plasma membrane sorts into a Stx6-positive, perinuclear sub-compartment devoid of furin or Tfn, and provide evidence that GLUT4 sorting through this sub-compartment is a prerequisite for acquisition of insulin responsiveness.

However, the molecular mechanism of membrane protein sorting from the ER to the INM has remained enigmatic.

If regulation of crossing is achieved only by regulating the presence of Robo on the plasma membrane through sorting mechanisms, then the expression of a form of Robo that cannot be sorted would lead to a comm phenocopy.

A commonality among these ideas is the belief that association of the C-terminal tail of PC1 with components of the trans-Golgi network (TGN) membrane, where sorting to the RSP is believed to be initiated, must occur, although binding via the prodomain has also been implicated.

Furthermore, the majority of raft-associated TM proteins are palmitoylated, with this being important for their within-membrane sorting (Levental et al., 2010), and palmitoylation of single-pass TM proteins may play a similar role in P. falciparum.