During the simulations, the model is perturbed from its stable equilibrium by a short current injection whose duration guarantees that the rapidly rising membrane potential will reach and cross its local maximum, creating a fully developed spike; see [12, 13, 47, 48] for more details.
(B ) Monotonous probability distribution of membrane time constant, whole cell capacitance, resting membrane potential, maximal rate of rise of spikes, relative offset of the input output curves, and action potential threshold data from the same set of cells as above.
Surprisingly, most patients are able to tolerate the intradialytic increase in hyperpolarization of the cardiac muscle membrane potential, induced by a rise in the intracellular/extracellular K+ ratio brought about by a reduction in the extracellular K+ value as a result of dialysis.
This was characterized by an initial rapid rise in membrane potential followed by a slowly ramping depolarization.
Ca2+ activates the BK channel SLO-1, which truncates the rise in membrane potential, preventing activation of the L-type voltage-gated calcium channel EGL-19.
Nigericin increased the uptake of TPMP, due to the rise in membrane potential, but had a negligible effect on MitoC uptake, probably due to the increase in uptake due to the higher membrane potential being counteracted by the loss of the pH-dependent accumulation of its weak acid (Fig. 4A).
We found that the majority of pyramidal neurons in layer 2, and some in underlying layer 3, have a distinctive late-spiking (LS) firing pattern, where an initial rapid rise in membrane potential is followed by a slowly ramping depolarization that leads to an action potential firing near the end of a just-threshold current step.
The interpretation of this result is that UCPs are most likely not involved in the rising temperature and the Cyt pathway activity that generates a membrane potential exerts a control over the temperature rise.
As shown in Figure 4A, 100 µM kanamycin induced a rapid depolarization of membrane potential as reflected by a sharp rise in the fluorescence intensity of the voltage-sensitive dye (DiBAC4(3)) in both vector control and prestin-expressing CHO cells (Fig. 4Aa,b), indicating cation influx induced by kanamycin as expected.
No statistically significant difference was observed for the rise time, resting membrane potential or the decay time (Table 1).
