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The membrane potential responses obtained on repeated presentation of each stimulation pattern provided a distribution of the bin averages for each time bin.
The eight different stimulation patterns were presented repeatedly, in random order, to obtain multiple membrane potential responses for each stimulation pattern.
The average intracellular membrane potential responses were typically unique for each stimulus pattern (Fig. 1H), so for each neuron we made such pairwise comparisons across all pairs of stimulation patterns available (N = 27).
With the whole cell patch clamp method, we recorded the intracellular membrane potential responses resulting from the synaptic inputs evoked by the spatiotemporal skin stimulation patterns (Fig. 1E,F).
In this study, we explored the feasibility of bioengineered primary olfactory sensory neurons (OSNs) as sensing elements of biomimetic olfactory-based biosensors, in which light addressable potentiometric sensor (LAPS) was used to monitor bioengineered OSNs membrane potential responses to odorant molecules.
The model predicts that ICcl responses are more multiplicative in spike count responses than in membrane potential responses.
Similar(31)
(h) Membrane potential response to 5 ms-long blue light pulses delivered at increasing rates (8 32 Hz) showing frequency-dependent AP failures (n = 7 neurons).
Neurons that exhibit a peak at finite frequency in their membrane potential response to oscillatory inputs are widespread in the nervous system.
In CDKAL1 KO cells, the glucose-stimulated mitochondrial membrane potential response was blunted (Fig. 7B).
A potential cause of the decreased mitochondrial membrane potential response to glucose is altered mitochondrial mass [30].
We hypothesized that altered mitochondrial glucokinase activity contributes to the poor membrane potential response to glucose stimulation.
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