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Inspiratory-inhibited neurons exhibit significantly more positive resting membrane potential, more negative voltage threshold and lower minimal current required to evoke an action potential under current clamp.
Only recordings with a resting membrane potential more hyperpolarized than −60 mV were included in the data analysis.
Although high dose mitoquinone reduced mitochondrial membrane potential, the positively charged mitochondrial-targeted cation, decyltriphenylphosphonium (mitoquinone without the coenzyme Q moiety), decreased membrane potential more than mitoquinone, but did not alter fuel selectivity.
Neurons with a resting membrane potential more depolarized than − 50 mV were discarded from the analysis.
Neurons with a resting membrane potential more positive than −40 mV upon breakthrough were rejected.
Neurons that had a resting membrane potential more depolarized than − 50 mV were discarded from the analysis.
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Depolarization block is a state of silence at membrane potentials more depolarized than those that support the generation of action potentials, also called spikes.
When ionic currents were blocked after removal of Ba2+ and addition of Co2+, depolarization led to voltage dependent outward currents which activated at membrane potentials more positive than −32.45±2.0 mV (n = 5; Figure 5B/C).
Single-channel open time of I323T increased with increasing [Ca2+]in and was most noticeable at membrane potentials more negative than −60 mV (Fig. 3 C ).
During the training, the membrane potential becomes more and more polarized with strong negative values on the classes that are not recognized by the selected neuron.
In addition, the patch clamp experiments showed that the overexpression of G88R, compared to TASK-4, leads to a significantly more pronounced shortening of the action potential duration (Fig 7C and E), while the maximal diastolic membrane potential is more hyperpolarized (Fig 7C).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com