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In both conditions, cells were able to maintain ATP levels despite the loss of membrane potential; however, different protein expression suggests different adaptation mechanisms.
Furthermore, increased UCP3 expression significantly attenuated ROS production in isolated mitochondrial without effects on membrane potential, however this effect is lost by Trx2 knock down.
Net flux of K+ at the BBB is critical for brain homeostasis, since changes in concentration affect resting membrane potential; however, net flux of this ion across the BBB is not well understood.
The reduction in membrane insertion seen when highly polar but uncharged residues replace Gly in the matrix-facing flanking sequences cannot be explained by the membrane potential, however; an interesting possibility is that it may reflect a transbilayer asymmetry in the translocon channel itself.
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A green fluorescent JC-1 probexiststs as a monomer at low membrane potentials; however, at higher potentials, JC-1 forms red-fluorescent 'J-aggregates'.
The decline in membrane potential was, however, found to be protected under CypD or JC15 depletion, respectively.
However, membrane potential and matrix pH changes were superimposable in WT and Opa1tg MAFs treated with oligomycin (Supplementary Fig. 3a-c), indicating a similar proton leak in these two cell lines.
However, membrane potential adjustment rather than K+ uptake has been hypothesized to be the major function of K+ channels in prokaryotes, although direct proof is still missing [3].
Data were collected only when resting membrane potential below −62 mV, however, those data were rejected if resting membrane potential were shifted more than ± 5 mV during the course of experiment.
In the model developed by Jasinski et al., however, the membrane potential and the cytoplasmic (mathrm{Ca}^{2+}) concentration can each influence the evolution of the other.
However, the membrane potential is unlikely to have a direct effect on oscillation periods since we found that, in the absence of polycations, periods were independent of pH.
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