In addition, Bhattacharya et al. [ 51] reported decreased mitochondrial membrane potential, enhanced cytochrome c release, reciprocal regulation of the Bcl-2 family, and increases of caspases 3 and 9 in alloxan-induced diabetes.
The phosphorylation of mitochondrial p53 by cyclin B1/Cdk1 stabilizes mitochondrial membrane potential and enhances mitochondrial ATP production, sequentially supplies the ATP required to repair damaged DNA and other critical cellular elements.
Furthermore, they decreased the mitochondrial membrane potential and enhanced the activities of pro-apoptotic factors caspase-3 and caspase-9 in a dose-dependent manner.
In that case, the accumulation of the weak acid into the basic mitochondrial matrix synergized with the membrane potential to enhance uptake [19].
It has been proposed that synchronization enables transient functional integration between specific neural groups as bursts of action potentials are consistently exchanged during the depolarized phase of the receiving neurons' ongoing membrane potential fluctuations, thereby enhancing communication between populations oscillating in synchrony [9].
By contrast, peaked post-spike membrane potential trajectories will enhance the ability of a cell to lock its discharge to oscillatory input.
Accordingly, PRELI can uphold mitochondrial membrane potential (ΔΨm) and enhance respiratory chain (RC) function, shown by its capacity to induce complex-I/NADH dehydrogenase and ATP synthase expression, increase oxygen consumption and reduce reactive oxygen species (ROS) production.
Our results showed that PS1 or AICD deficiency reduces ATP levels and enhances mitochondrial membrane potential.
In particular, the Ca2+ activated K+ channel KCa3.1 plays an important role in Ca2+ signalling through its ability to maintain a negative membrane potential during cellular activation, which enhances Ca2+ influx from the extracellular fluid [ 23- 25].
Therefore, maintaining the mitochondrial membrane potential may be favorable for enhancing the tolerance of cells toward environmental stress.
