But this requires to replace the firing condition (4) by another condition stating what the membrane potential does during the spike.
This effect is not unexpected because the membrane potential does not directly enter the cost function in the parameter estimation procedure.
However, as opposed to ROS production generated by reverse electron transport on succinate, reduced membrane potential does not appear to underlie the effect of mitoQ to increase ROS during forward electron transport (respiration on complex I substrates).
Despite these changes, the rate of glycolysis, the type of glycolytic end-product (>95% lactate) and the magnitude of the membrane potential did not differ between GCDM- and GM17-grown cells (Figure S3), suggesting that carbon metabolism and energy status were not affected to a great extent by the different media.
The filtered membrane potential data were then grouped into similar voltage ranges to ensure that average membrane potential did not differ between hit and catch conditions.
Thus, a positive correlation between resonance frequency and membrane potential did not lead to increased network oscillation frequency for stronger input.
Valinomycin, which was used as a positive control and is known to depolarize mitochondrial membrane potential, did induce a significant decrease in mitochondrial membrane potential and cellular ATP content.
Recordings were accepted when the amplitude of subthreshold stimulus-evoked responses before the STDP induction protocol was stable and when the resting membrane potential did not change by more than 8% during the course of the recording.
The loss of membrane potential did not affect the control (endogenous) proton conductance at fixed energization duration, implying that the HNE-activated and endogenous proton leak pathways through ANT differ.
