Changes in membrane potential were calculated using partial differential equations that were integrated using the simulation package NEURON [ 27].
Differential mitochondrial membrane potential decrease, mitochondrial enzymatic dysfunction, and mitochondrial morphological alteration are exhibited in two cell lines.
These results suggested simulated microgravity induced a differential regulation of membrane potential in cerebral and small mesenteric VSMCs, respectively, which are in general agreement with previous report [16], [21].
The time curse of the membrane potential during the spike is described by differential equations, like Hodgkin-Huxley's [35].
According to the equivalent circuit (Additional file 1: Figure S6 of supplementary data), the cell membrane potential is distributed between the electrode and differential amplifier resistances.
Therefore, the membrane potential can be represented by the ordinary differential equation: C f dV f/ dt) = − G f(V f − E f), where C f is the fibroblast membrane capacitance, V f is the membrane potential of the fibroblast, E f is the fibroblast resting membrane potential, and G f is the fibroblast membrane conductance [ 14].
The model is a system of 12 nonlinear coupled differential equations: one describing the membrane potential V (1), two equations for the IK1, one per Ih, IDRK, and per ICa; 6 equations for the BK currents IBKS and IBKT; 1 equation for the calcium dynamics.
This single-compartment model consists of five ordinary differential equations that describe the dynamics of the membrane potential, V, and four ionic gating variables,, and : (3a).
Here, the dynamical behavior of the ensemble of neurons is encoded in a stochastic differential equation for the evolution in time of membrane potential v ( t ) of a typical neuron representative of the network.
The interactions of the designed PrAMP, Chex1-Arg20, and its dimeric and tetrameric oligomers with different model membranes were investigated by circular dichroism spectroscopy, dynamic light scattering, zeta potential, differential scanning calorimetry, and dye leakage.
