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The uptake of diphenhydramine was significantly inhibited by pretreatment with metabolic inhibitors, but was insensitive to extracellular sodium and membrane potential in hCMEC/D3 cells (Table 2), suggesting the involvement of a transporter having similar energy and membrane potential dependencies to those of TR-BBB13 cells.
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Though the mechanism of extra-matrix Ca2+ dependency of mitochondrial Ca2+ uptake has been well characterized, the mechanism of membrane potential dependency of mitochondrial Ca2+ uptake has not been completely characterized.
Though the mechanism of extra-matrix Ca2+ dependency of mitochondrial Ca2+ uptake has been well characterized both experimentally and mathematically, the mechanism of membrane potential dependency of mitochondrial Ca2+ uptake has not been completely characterized.
Specifically, the present paper provides an alternate (improved) biophysical model of the uniporter that overcomes the limitations of our previous uniporter model by mechanistically recharacterizing the membrane potential dependency of mitochondrial Ca2+ uptake via the uniporter.
The RF model was modified to include a linear, positive dependency of the resonant frequency on the membrane potential and we systematically manipulated the slope of this dependency (Fig. 11 A, top) in IF RF networks.
Mitochondrial membrane potential.
the mitochondrial membrane potential.
Membrane potential (mV).
Mitochondria membrane potential.
a) Mitochondrial membrane potential.
Em membrane potential (V).
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