The model describes a novel mechanism of excitability based on the membrane potential-dependence of Ca2+ currents and simultaneous intraciliary Ca2+-concentration mediated inhibition of Ca2+ channels.
In the diagram (a), we show the absolute maxima (unlike to the local maxima shown in the bifurcation diagrams of Fig. 5) of the membrane potential in dependence of the stimulation frequency.
In order to demonstrate how these results are related to different synchronization regimes (1 1 or higher order) in (c) and (d), we present the standard bifurcation diagrams, which show the local maxima of the membrane potential in dependence of the stimulation frequency.
Statistical comparison of these parameters showed that IKv in MASMCs is inactivated at more negative membrane potentials, its dependence on the conditional prepulse potential is steeper, and it has less noninactivated current than IKv in PASMCs; these differences in inactivation characteristics were significant (Table 1).
In a conductance-based model, such as a discrete stochastic version of the Hodgkin–Huxley equations, the vector ( N 1 ( t ), …, N K ( t ) ) would represent the number of ion channels in each of K distinct states, and the transition rates could vary with time, e.g. through dependence on membrane potential or second messenger concentration.
Voltage-gated Na+-channels exhibit a dual dependence on membrane potential.
The experimental data-based [ 66] model for the inward Ca2+ current dependence on membrane potential predicts a significant reduction of the inward Ca2+ current amplitude as a function of membrane depolarization.
The model predictions for the steady-state dependence of transmembrane potential on intraciliary Ca2+ concentration and the dynamic Ca2+ current amplitude dependence on the membrane potential are shown in Figure 6A and 6B, respectively.
Reports in other systems on the dependence of resonant frequency on membrane potential do exist, but results are dependent on the frequency band, the particular neuronal system, the preparation, and so on.
In the calcium compartment, the dynamics of (ca_{i}) depends on the neuronal membrane potential v. We can represent this v-dependence by considering a family of (ca_{i}) nullsurfaces, each defined for v fixed.
