Apoptosis was documented by changes in mitochondrial membrane potential, alteration of the plasma membrane, caspase 3 activation and DNA fragmentation.
Mitochondrial membrane potential alteration was detected using a JC-1 staining kit (Beyotime) according to the manufacturer's protocol.
We further assume that in response to the fast membrane potential alteration from ψ0 to ψ1, the K+ conductivity is changing exponentially with a characteristic time τ K +.
Additionally, BPA-induced apoptosis was associated with mitochondrial defects in β cells, as evidenced by depletion of ATP, release of cytochrome c, loss of mitochondrial mass and membrane potential, and alterations in expression of genes involved in mitochondrial function and metabolism.
Changes in membrane potential induce alteration in the firing of nerve impulses by the afferent neurons supplying each hair cell.
The anticancer activity of both extracts was compared with that of paclitaxel as positive control and the effect was assessed by MTT assay, mitochondrial membrane potential (MMP) alteration, intracellular reactive oxygen species (ROS) measurement and nuclear morphology with the appearance of apoptosis.
We show that loss of DJ-1 caused impaired mitochondrial respiration, increased intramitochondrial reactive oxygen species, reduced mitochondrial membrane potential and characteristic alterations of mitochondrial shape as shown by quantitative morphology.
Spontaneous depolarization of membrane potential, fired by alterations in membrane currents and ion channels, occurs during pregnancy.
It was suggested, that anodal tDCS modulates pain perception by shifts of the resting membrane potential and consequent alteration of the corticospinal excitability at the stimulation site.
Mitochondrial membrane potential (Δ ψm) alteration is an important target for cancer diagnosis.
