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Caveolin-3 maintains a plasma membrane pool of dysferlin by inhibiting dysferlin endocytosis through a clathrin-independent pathway [38].
Degradation of the membrane pool of β-catenin in skeletal muscle is mediated by the Ozz-E3 ubiquitin ligase complex [49].
To investigate this, we applied surface biotinylation to specifically label the plasma membrane pool of D2 receptors and assessed turnover of this receptor pool as a function of time.
Interestingly, these results suggest that the effect on denticle polarity of Wg in the armF1a (M/Z) mutants may be through the membrane pool of Arm at the adherens junctions.
These results suggest that the enhancement of functional CP-AMPARs at layer 2/3 synapses of GluR1-S845A mutares are not associated with an up-regulation of extrasynaptic plasma membrane pool of GluR1 homomers.
Most of the 1H-NMR mobile lipid signal possibly comes from the cytoplasmic pool of TGLs, but based on microscopy studies and the sensitivity of the signal to paramagnetic gadolimium ions (which bind to membranes), the possibility of a membrane pool of TGLs cannot be ruled out [25].
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The intensity of the nuclear fluorescence signal decreased faster in the cell in which the plasma membrane was repetitively bleached compared to an adjacent control cell (Figure 5B), suggesting that the nuclear and plasma membrane pools of Rac1 are connected.
Moreover, in epithelial cells of the Drosophila germ band, several distinct plasma membrane pools of E-Cadherin have been identified, each of which bind different populations of Actin [ 29 ].
COS-7 cells transiently expressing either wild-type SR-BI or SR-BI/CD36 chimeric receptors were assessed for their ability to redistribute plasma membrane pools of FC upon treatment of cells with exogenous cholesterol oxidase 48 h post-transfection.
We employed pharmacological inhibition of PI4KIIIα (an enzyme responsible for the plasma membrane pools of PI4P and thus PI4,5P2) (Balla et al., 2008; Balla et al., 2005) activity to test this model.
Similarly, all chimeric receptors with swapped regions in the C-terminal half of the EC domain of SR-BI were able to reorganize plasma membrane pools of free cholesterol to an extent similar to that of wild-type SR-BI, as judged by the membrane content of cholestenone upon addition of exogenous cholesterol oxidase.
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