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For electrochemical regulations of the intracellular metabolisms, lipophilic electron mediators with cell membrane permeability have been conventionally used.
Moreover, both dyes with good membrane permeability have been successfully used to image ribonucleic acid in nucleoli and cytoplasm in living cells by confocal and two-photon fluorescence microscopy.
The extents of lipid peroxidation and membrane permeability have been used as indices of salt injury and tolerance in Amaranthus (Battacharjee and Mukherjee 1996).
Oral bioavailability or membrane permeability have often been connected to simple molecular descriptors such as logP, molecular weight, or the counts of hydrogen bond acceptors and donors in a molecule [3].
For example, mutations in ompF, a gene implicated in membrane permeability, have been isolated in Escherichia coli grown in lactose-limited conditions (Zhang and Ferenci 1999).
Ethylenediaminetetraacetic acid and polyethyleneimine that disturb outer membrane permeability have been reported as RMA for novobiocin against P. aeruginosa and Stenotrophomonas morelense[ 33, 34].
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Poor aqueous solubility and extensive metabolism have been implicated for this but the role of membrane permeability has not been investigated.
Increased membrane permeability has been suggested to reflect the extent of lipid peroxidation caused by ROS (Sairam et al. 1998).
Recently, a selection method comprising the composite of weighted physicochemical parameters (CNS PET multiparameter optimization or 'MPO'), free fractions in plasma and the brain, as well as membrane permeability has been reported [10].
Reduced outer membrane permeability has also been described and generally in association with plasmid-mediated β-lactamases [4].
OmpC is one of the major outer-membrane porins that are thought to influence permeability of the outer membrane, and reduced membrane permeability has been observed in an ompC mutant of Y. enterocolitica [26].
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