Sentence examples for membrane orientation of from inspiring English sources

These findings demonstrate unequivocally the presence of functional TM domains in CaBP7 and CaBP8 that are responsible for driving the correct membrane localisation and membrane orientation of the Ca2+-sensors.

We next determined the sub-mitochondrial localization and membrane orientation of PTPIP51 using three different assays.

We also elucidated the membrane orientation of the N- and C-termini of DHCR24, for which the TMD prediction programs gave different results.

To determine the membrane orientation of the N- and C-termini, equivalent amounts of membrane were treated with trypsin as described [ 13].

The relationship between membrane orientation of an estrogen and its access to the ligand-binding site in membrane ERα, however, is at this point a matter of speculation, but it is clear that both E2 and E4 bind to ERα regardless of whether it is localized in the nucleus or the plasma membrane.

Nine independent duplication events in DUF606 (5 paired, and 4 fused) can be demonstrated with evidence of evolution from 4 TM units to paired or fused genes that give fixed and opposite membrane orientation of the two DMT domains and resulting protein activity [ 26].

Given this inferred organization and integral-membrane orientation of the Hyq endo-hydrogenase complex (for which we as yet lack direct experimental evidence), one implication is obvious: the Hyq endo-hydrogenase might physically interact with Mo-dinitrogenase so as to channel evolved H2 as substrate for membrane-driven respiration and oxidative phosphorylation.

A murine Igκ signal sequence was added to the N-terminus to ensure proper membrane orientation, addition of such a signal sequence has previously been shown to not adversely affect BKα topology.

KLA Pen may exert its deleterious and selective action on cancer cells by the formation of pores with an oblique membrane orientation and establishment of important hydrophobic interactions.

As expected, exosomes bound only to antibodies recognizing the extracellular domains, not to the ones recognizing the intracellular domains, indicating that the extracellular domains face the outside of the exosome, which means that the exosomes have the same membrane orientation as that of the parent cell, supporting the inward budding biogenesis pathway of exosomes.

To further investigate the effect of lipid tails and headgroups on the membrane orientation and localization of FK1TMD, we performed CGMD simulations in three different lipid tails and also a mixture of headgroups that closely mimics the in vivo Golgi membrane composition.