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These membrane microdomains represent versatile devices for compartmentalizing different signaling functions.
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There is a consensus to accept that the plasma membrane raft microdomains represent the gateway for the entry and exit of Filoviruses and generation of VLPs.
Studies using fluorescently- GFP -labeled YuaG, which localizes as a discrete and highly mobile fluorescently- GFP -labeledrane, suggest that it might represent membrane microdomains in analogy to the situation in vertebrates [Peter Graumann and fluorescently- GFP -labeled of Freiburg; personal communication].
This result suggested that these membrane microdomains could be important to elastin receptor complex function.
Caveolae are plasma membrane microdomains that play important roles in signalling and endocytosis.
Membrane microdomains tend to be insoluble in mild non-ionic detergents.
Based on the fact that APP is a type I membrane protein that is proteolytically processed to form Aβ in sphingolipid-enriched membrane microdomains, the possibility that modulation of membrane lipid composition could represent a novel means to regulate Aβ production presents a plausible basis for AD therapeutic intervention [ 9, 11, 49– 52].
The "membrane microdomain ortho-signalling therapy" represents an emerging concept that opens a new therapeutic window for the treatment of metabolic disorders.
Acylation, especially covalent linking of saturated fatty acids, represents a targeting signal for many proteins that interact with membrane microdomains [17].
Steroid- and sphingolipid-enriched membrane microdomains, often referred to as lipid rafts, play an important part in cellular invasive structures.
Thus, additional interaction partners in the CCPs are required for EGFR to be sorted into these plasma membrane microdomains.
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