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Membrane microdomains, called lipid rafts, are distinct in their lipid and protein contents from the bulk of the membrane [2], [3], [4].
We previously showed that phagocytosis of Leishmania proceeds through a subset of lipid-enriched membrane microdomains called caveolae, which are enriched in cholesterol, ganglioside M-1 (GM-1), GPI anchored proteins and caveolins-1, -2 and -3 [7]–[9].
Caveolin-1 (CAV1), the primary structural component of specialized plasma membrane microdomains called caveolae, is a crucial regulator of tissue fibrosis.
Structural sphingolipids such as galactosil-ceramide, one of the substrate of the GALC enzyme, are localized in membrane microdomains called rafts.
In the present work, we investigated whether cell susceptibility to TRAIL ligation could be due to the presence of TRAIL death receptors (DRs) 4 and 5 in membrane microdomains called lipid rafts.
PI3K and c-Cbl are known to interact with growth factors in the cell membrane microdomains called lipid rafts that serve as platforms where signaling molecules are recruited to membrane-associated kinases, allowing functional interactions.
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The mosaic fluid model of Singer and Nicolson (Singer and Nicolson, 1972) was recently reviewed in light of a new concept, representing cell membranes as a mosaic of highly structured microdomains, called membrane rafts, alternating with less organised regions (Lingwood and Simons, 2010).
Tetraspanins associate with themselves or with other membrane proteins to form microdomains, called the tetraspanin web.
A procedure based on surface plasmon resonance (SPR) is proposed to monitor the lateral mobility of lipid molecules in solid-supported bilayer lipid membranes (ssBLMs), an essential prerequisite for the formation of important microdomains called lipid rafts (LRs).
The complex and dynamic architecture of biological membranes comprises of various heterogeneities, some of which may include lipid-based and/or protein-based microdomains called "rafts".
Our results can be used to estimate the residence time of the receptor on the membrane if interactions with any scaffolding molecules are neglected (the latter are mostly concentrated in a local microdomain called the PSD).
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