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Substitution of the aromatic module with another benzene-containing domain that maintains membrane localization generates a structurally distinct compound that nonetheless has similar biologic activities as EerI.
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Since ZAP-70 does not translocate to the TCR complex in Rho-deficient T cells, to determine if defective T cell development in Rhoh-/ mice was due to defective ZAP-70 membrane localization, we generated a retroviral vector expressing Myr-ZAP-70 or control vector and utilized these vectors to transduce Rhoh-/ low density bone marrow cells (LDBM).
This membrane localization has recently generated interest in the use of nucleolin as a tumor marker and therapeutic target.
Dual oxidation maturation factor 2 (DUOXA2) is a transmembrane protein required for plasma membrane localization of the hydrogen peroxide generating enzyme DUOX2.
Both miRFP670nano internal fusions demonstrated perfect membrane localization, co-localizing with mVenus containing a CAAX-motif for membrane targeting.
We took advantage of the reconstitution of IFP fragments to generate stable complexes of PDK1 and AKT1 in the absence of PI3K activity and membrane localization.
InvG membrane localization and proposed pathway for pore assembly and membrane insertion.
This result directly shows the membrane localization of the de novo bR onto the PL membrane.
Plasma membrane localization of apoptotic caspases for non-apoptotic functions.
This directed membrane localization is controlled by means of cholesterol which inhibits spontaneous membrane integration of protein23.
Extended Data Fig. 7 The MAPK PSD4 ARF6 axis mediates KRAS*-dependent SDC1 membrane localization.
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