Sentence examples for membrane localisation of from inspiring English sources

The membrane localisation of RNase E is mediated principally by an amphipathic α-helix localised 30 to 45 residues to the c-terminus of the catalytic domain (residues 565 582 in E. coli RNase E), which is conserved in RNase E homologues of the β- and γ-Proteobacteria [79].

Phosphoinositide-3-kinase (PI3K) activation leads to increased NIS expression in MCF-7 cells and has also been shown to diminish membrane localisation of the protein in these cells [19], [20].

Since our recent work suggests that CFTR creates a membrane-anchored hub controlling the membrane localisation of at least four different protein kinases, [19], [42], [43], [44], [45], [46], the loss of wild type CFTR at the membrane is predicted to disrupt multiple pathways given that all these protein kinases have been implicated in inflammatory signalling.

To exclude a possible underdosing we analysed membrane localisation of ERBB2.

Indeed, we observed the membrane localisation of RhoA was more obvious in unstimulated cells.

Thus, both lipophilicity and membrane localisation of vitamin E explain its antioxidant activity.

The PID protein kinase is required for dynamic changes in plasma-membrane localisation of PIN auxin transporters and thereby auxin transport direction [ 32- 34, 74].

TdTomato is localised to the plasma membrane by fusion to the membrane localisation domain of the Lyn intracellular kinase (Trichas et al., 2008).

Reduced intracellular and increased plasma membrane-localisation of the Gleevec-sensitive PDGFRα-V561D can be observed upon inhibition of its constitutive activity.

In N2A cells expressing truncated versions of CaBPs7 and 8 we observed a complete loss of membrane localisation and the proteins were entirely cytosolic.

These findings demonstrate unequivocally the presence of functional TM domains in CaBP7 and CaBP8 that are responsible for driving the correct membrane localisation and membrane orientation of the Ca2+-sensors.