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Deoxygenation-induced elevation of [Ca2+]i might require or be sustained by membrane hyperpolarization caused by KCa3.1 activation.
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Perforated patch recordings from single cultured isolated β-cells showed that control (WT and RIPCre) β-cells responded to low glucose (10 mM to 2 mM) by membrane potential hyperpolarization causing cessation of action potential firing, actions reversed on returning to 10 mM glucose.
Mitochondrial hyperpolarization caused by IL-6 is uncoupled from the production of ATP by oxidative phosphorylation.
Because activation of Kir2.3 channels causes membrane hyperpolarization [36], PREGS may decrease excitability of neurons and glial cells in these regions.
This causes membrane hyperpolarization and the relative refractory period in the ureter [18].
14-3-3 14-3-3 14-3-3 14-3-3wn to interact withasusicoccin, thearlierl toxin that causes membeene hyperpolarization through activation of plashownembrane H+Atoase [ 25].
In pancreatic β-cells, a similar increase in the KATP current would be expected to cause membrane hyperpolarization and reduce or abolish the membrane depolarization evoked by glucose.
To examine the potential role of β-NAD rather than ATP as a purinergic transmitter in the mouse stomach, we examined the effectiveness of β-NAD in causing membrane hyperpolarization.
This study showed that Pd-la was a potassium channel opener (KCO) that increased the extracellular K+ level and caused cellular membrane hyperpolarization.
Furthermore, it has been established previously that activation of D2-autoreceptors decreases the firing and causes subsequent membrane hyperpolarization of recorded DA neurons and this effect is most likely mediated through GIRKs (G protein-coupled inward rectifying potassium channels).
Lubiprostone caused SC-51322-insensitive membrane hyperpolarization and no effect on [cAMP]i.
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