Exact(1)
Substrate enters the TMD, partially crossing the bilayer as far as a membrane gate.
Similar(58)
In many bacteria, secretins from the type II secretion system (T2SS) function as outer membrane gated channels that enable passage of folded proteins from the periplasm into the extracellular milieu.
To analyze whether the change in Ba2+ current density is due to modulation of the CaV1.3 pore or due to less CaV1.3 protein in the cell membrane, gating currents of CaV1.3 channels were measured.
NBD dimerization causes TMD rearrangements, closing the entry gate and opening the membrane gates.
This mutant channel assembles in the membrane, gates with applied pressure, and protects against hypoosmotic shock when overexpressed.
Gate 1 is formed by the 'cone' in the outer membrane and gate 2 by the N1 domain at the base of PilQ, enclosing an empty periplasmic vestibule.
Light sensing involves contraction of the photoreceptor cell membrane physically gating the light-sensitive channels.
TJ proteins have three mutually exclusive functions; a fence function which differentiates between proteins of the apical and basolateral membranes, a gate function which controls the paracellular passage of ions and solutes in-between epithelial and endothelial cells, as well as a bridge function which facilitates the communication between neighboring cells [9], [10].
The cell membrane contains gated pores called transporters that allow particular molecules to pass through it.
To our knowledge, simultaneous mobility in the plasma membrane and gating has not been previously reported for any ion channel, and are explored further below.
Diversity in their function has been reported in which LC3B seems to be mostly involved in the elongation of the phagophore membrane, whereas GATE-16 is more important for autophagosome maturation at a later stage.
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