Sentence examples for membrane for activation from inspiring English sources

Signalling is initiated, when active RAS recruits RAF to the plasma membrane for activation through a complex process requiring lipid and protein binding, conformational changes, and regulatory phosphorylation and dephosphorylation events.

In turn, MEK, ERK, and scaffold proteins translocate to the plasma membrane for activation.

The cascade is controlled by the Ras GTPase, which recruits Raf from the cytosol to the plasma membrane for activation.

Here, we termed "PepDisplay" as a technology for displaying peptide ligands on a plasma membrane for activation of either endogenous or heterologous GPCRs produced in yeast cells.

These results reveal the engineering logic behind the recruitment of elements of the module from the cytosol to the membrane for activation.

Akt contains an amino-terminal pleckstrin homology (PH) domain that serves to target the protein to the membrane for activation [ 21, 22].

Ras GTPases are considered cytoplasmic proteins that must be localized to cell membranes for activation, and there are few evidences of the presence of any Ras isoform in nuclei of eukaryotic cells.

Thus, the members of the Ras family of proteins are considered cytoplasmic proteins that must be localized to the plasma or other intracellular membranes for activation, but there are only two studies showing the nuclear presence of Ras isoforms [11], [12].

The important point is that activation of Cav channels requires transient depolarization from a hyperpolarized membrane potential for activation.

Calcium is not only an important second messenger in the generation of force via calcium-calmodulin-dependent myosin light chain kinase, but also depolarizes the plasma membrane, allowing for activation of other voltage-dependent ion channels (Word et al, 1994; Brainard et al, 2007).

Given the clear connections between the three BCL-2 subfamilies, which can be singularized at specific active domains, and given the protagonism of the lipid membrane for their activation mechanism, a thorough comparative study of membrane activity and membrane interactions of analogous fragments from the three types of proteins is key to understand the bases of their different behavior.