However, a subset of tumors of each of these ten cancer types showed high Ep-ICD membrane expression that correlated with high EpEx expression on the membrane detected using an Ep-CAM external domain (EpEx) specific antibody (MOC31), suggesting increased expression of the full length protein as detected by Ep-ICD and EpEx specific antibodies.
On the contrary, we have, also, observed that PCM-c-KitR membrane expression is correlated with MCGD and lower MVD in G1 and G2 CMCTs subgroups.
χ analysis demonstrated that the membrane and cytoplasmic SK1 expression correlated with age.
In fetal membranes, the levels of relaxin gene expression correlated with fetal membrane surface area (r = 0.76) and was significantly greater (P <.008) in the membranes from macrosomic infants (4020-4729 g) compared with those normally grown (2855-3830 g).
Nuclear expression of pY530Src correlated negatively with oestrogen receptor (ER) status (χ P<0.001), whereas cytoplasmic phosphorylated and dephosphorylated Y530Src expression correlated negatively with membrane c-Src expression (χ P=0.008, χ P<0.001).
Furthermore, a recent study showed that AR expression correlated with activated membrane receptor kinase EGFR in TNBC patients, and concomitant administration of anti-androgen bicalutamide with EGFR inhibitor decreased the amount of AR, along with an antiproliferative effect [ 7].
Figures 2d f show that abrogated CHOP expression correlated with reduced levels of cardiolipin peroxidation, preserved mitochondrial membrane potential ΔΨM, absent nuclear condensation, and low caspase-3 activation.
In addition, patients with an increase in N-Ras membrane expression had lower levels of PSA at relapse (p = 0.02) and expression correlated with phosphorylated MAP kinase (p = 0.010) and proliferation index (Ki67, p = 0.02).
hENT1 mRNA expression correlated with sensitivity to ara-C and also seemed to correlate with sensitivity to 2-CdA, DAC and dFdC, indicating that transport across the cell membrane is an important step for deoxynucleoside analogue induced cytotoxicity.
