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At extreme high temperatures, biological performance also falls off rapidly: problems include insufficient capability of respiratory and circulatory systems to meet increased demand for oxygen (Portner 2002), protein denaturation, and membrane dysfunction due to increased fluidity (Hochachka and Somero 2002).
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A very recent study suggests that the increased levels of sphingomyelin observed in Niemann Pick disease type A, cause lysosomal dysfunction due to lysosomal membrane permeabilization [ 65].
In addition, quercetin caused mitochondrial dysfunction due to collapse of mitochondrial membrane potential.
ROS-mediated mitochondrial permeability transition pore (mPTP) opening causes mitochondrial dysfunction due to mitochondrial matrix swelling and outer membrane rupture.
Sudomotor dysfunction due to small fiber neuropathy can be observed very early in pre-diabetes.
Early hypertension is associated with left ventricular diastolic dysfunction due to increased end-diastolic pressure.
Thus, microvascular dysfunction due to pericyte degeneration may initiate neurodegenerative changes[123].
He had liver dysfunction due to hepatitis C infection and diabetes mellitus.
Microcirculatory dysfunction due to excessive nitric oxide production by the inducible nitric oxide synthase (iNOS) is often seen as a motor of sepsis-related organ dysfunction.
Our study demonstrates that intracranial hypotension can induce higher frequency of audiovestibular dysfunction, which may be attributed to both irritation or dysfunction of the peripheral labyrinth or vestibulocochlear nerve, and brainstem or cerebellar dysfunction due to brain sagging.
Importantly, peripheral vasodilation (relative hypovolemia and low systemic vascular resistance) coexist with cardiac dysfunction (left ventricular (LV) diastolic and systolic dysfunction secondary to primary myocardial injury or right ventricular dysfunction due to pulmonary hypertension) resulting in ventriculoarterial decoupling.
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CEO of Professional Science Editing for Scientists @ prosciediting.com