There are strong indications that LC-PUFAs play an important role as membrane components involved in our neural system (Uauy et al. 2000).
Menaquinones and the cytochrome CymA (tetrahaem quinol dehydrogenase) are the crucial cytoplasmic membrane components involved in the pathway, which then branches off via a network of periplasmic cytochromes to three outer membrane cytochromes.
The infectability of cell lines by adenovirus has been reported to be dependent on the presence of coxsackie and adenovirus receptor (CAR) and αβ integrins, which are two cell membrane components involved in viral attachment and internalisation (Wickham et al, 1993; Bergelson et al, 1997).
Our analysis of the L. pneumophila Lens genome revealed a unique ORF sharing significant homology with the TolC protein from Escherichia coli, which is the prototypical outer membrane channel component involved in MDR and type I secretion [22], [23], [24].
Of the 5 transcripts expressed only in the more permissive population CQG, one transcript (CPIJ003600-RA) codes for a ctl transporter and its functional parental attribute suggest it is a cellular component involved in membrane transport and is 4-fold more highly expressed.
Interestingly, a recent study linked the TGN exit of lysosomal membrane proteins to GGA3, the same component involved in the exit of MPRs.
Overall, our results provide evidence in support of at least two pathways for plastid TA biogenesis that are distinguished by the nature of their molecular targeting signals and the membrane protein and lipid components involved.
OEP9 is distinct from Toc33 and Toc34, however, with regards to the nature of its molecular targeting signal and the membrane protein and lipid components involved in its insertion into the chloroplast outer envelope.
Low affinity binding motifs are present in endocytic proteins [103] and it has been suggested that low affinity protein-protein interactions are essential for the rapid and accurate coordination between the vast range of components involved in membrane trafficking pathways such as endocytosis [104,105].
The conserved co-cycling genes encode components of the ribosome (particularly the small subunit), plasma, and thylakoid membrane components, or are involved in stress response (Fisher exact tests, P < 0.05).
