Sentence examples for membrane cholesterol levels from inspiring English sources
Multidrug-resistance (MDR) in cancer cells is often associated with marked changes in the membrane cholesterol levels.
Modulating cholesterol metabolism can improve CD8+ T-cell-mediated immunity against tumours; genetic or pharmacological inhibition of the cholesterol esterification enzyme ACAT1 led to higher plasma membrane cholesterol levels, better T-cell receptor clustering and signalling, improved immunological synapse maturation, and enhanced antitumour activity in mice.
However, this group of proteins is known to be transcriptionally regulated by the sterol regulatory element-binding factor-2 (Srebf2), which is activated by cleavage from the endoplasmic reticulum (ER) membrane when the membrane cholesterol levels are decreased [24].
Importantly, membrane cholesterol levels are closely linked to the A β-induced calpain activation and tau toxicity [ 204].
There are indications that low membrane cholesterol levels have a considerable impact on the pathogenesis of AD [ 163].
The results showed that COD-B treatment induced membrane cholesterol levels despite cholesterol repletion by the exogenous cholesterol.
A direct link between the membrane cholesterol level and Bax activation has been proposed as in liposomes, cholesterol decreases membrane fluidity and inhibits Bax oligomerization induced by tBid without blocking its insertion.
Accordingly, a reduced lysosomal membrane cholesterol level is associated with increased permeability to protons and potassium ions; this, in turn, causes an osmotic imbalance and destabilization of the lysosomal membrane [ 141– 141].
This combined approach leads to the hypothesis that the major lipid metabolic effects of replacing FO with VO in salmon diets are mediated by SREBP2, a transcription factor which responds to reductions in membrane cholesterol level caused by reduced cholesterol in VO based diets.
The nature of this association is unknown but depends on membrane cholesterol-levels [4].
Indeed, the levels of cholesterol in the neuronal membranes were measured after replenishment, and in 30 DIV hippocampal neurons, the cholesterol-MβCD/cholesterol mix produced a 19% increase in membrane cholesterol: the cholesterol levels in membrane preparations rose from 0.144 ± 0.002 to 0.171 ± 0.011 μg cholesterol/μg of protein.
