Sentence examples for membrane channel function from inspiring English sources

An altered membrane channel function and an imbalance between excitatory and inhibitory factors seem to have a central role in the pathogenesis of the two disorders [28, 35 37].

Our results here unveil a novel role for flotillin-1, as a scaffolding protein affecting the regulation of membrane ion channel function.

These compounds are either capable of correcting the trafficking of CFTR mutants ("correctors": agents that ensure the expression of the mutated protein at the apical plasma membrane) or improving channel function ("potentiators": agents that reinstate the channel function of mutated CFTR proteins that are orthotopically expressed).

However, in both the lipid analysis and functional study, only positive findings have meaning: other lipids may be involved in channel structure, and there may be effects of membrane composition on channel function not revealed by the TSF liposome assay.

The DHA/AA (n-3/n-6) ratis importantant in the maintenance of an appropriate level of biological membrane fluidity, which is in turn, essential for ion channel function, membrane receptor activity and the release of neurohormones, i.e. the signaling processes of every cell.

Weber et al. recently evaluated cells with CFTR mutations that produce proteins that are trafficked normally to the cell membrane but lack Cl− channel function.

- Similarly, silencing c-Cbl increases the plasma membrane stability and Cl- channel function of the wild type (WT -CFTR.

Indeed, targeting Dab2 or the CFTR associated ligand (CAL) increases plasma membrane stability and Cl- channel function of ∆F508-CFTR.

Recent nerve excitability studies suggest that the recovery cycle after a single supramaximal stimulus provides useful information about axonal membrane potential and ion channel function in neuropathies.

Indeed, both the PH1 helix G137I mutant and the M4 W275S mutant caused a marked reduction in the ability of membrane potential to affect channel function.

These two measurements are sensitive to alterations in muscle membrane potential and ion channel function, and in probable CIM muscle VRC measurements indicate that muscle fibres are depolarized and/or sodium channel inactivation is increased [ 20].