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Thirdly, for the myelin to reduce the effective axonal membrane capacitance well, there needs to be little current flow under the myelin sheath [ 6, 120].
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A number of factors can influence the dynamics of the EJP, including membrane capacitance and resistance, as well as changes in voltage-gated channels in the membrane.
We model the system as two capacitors in series: The first is the well-known lipid bilayer membrane capacitance Cmembrane (from prior studies as well as our own measurements described in the Supporting Information 3 to be ∼0.6 μF/cm).
We found that the number of vesicles secreted at the footprint of the cell correlated well with the membrane capacitance increase upon depolarization of the cell.
Passive membrane properties commonly investigated in studies monitoring neuronal development include input resistance (Rin), membrane capacitance (Cm), and the membrane time constant as well as the resting membrane potential (RMP).
The membrane capacitance of the cells was calculated from the integral of the uncompensated capacitive artefact.
where C m is the membrane capacitance.
Data normalized to the cell membrane capacitance.
(C_{m}), the neuronal membrane capacitance, is (21~mbox{pF}).
Equivalent circuit of our measurement system (Cm: cell membrane capacitance, Em: cell membrane potential, Rm: cell membrane resistance, Rleak: junction leakage resistance, Re: electrode resistance, Ce: electrode capacitance).
As a result, increase in the membrane capacitance is recorded.
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